Sepsis-Related Articles of Interest

Silver SA, McQuillan R, Harel Z, Weizman AV, Thomas A, Nesrallah G, Bell CM, Chan CT, Chertow GM. How to Sustain Change and Support Continuous Quality Improvement. Clin J Am Soc Nephrol. 2016 May 6;11(5):916-924. doi: 10.2215/CJN.11501015. Epub 2016 Mar 25. PMID: 27016498; PMCID: PMC4858491. Abstract

Hibbert, P.D., Basedow, M., Braithwaite, J. et al. How to sustainably build capacity in quality improvement within a healthcare organisation: a deep-dive, focused qualitative analysis. BMC Health Serv Res 21, 588 (2021). https://doi.org/10.1186/s12913-021-06598-8. Abstract

Doyle C, Howe C, Woodcock T, Myron R, Phekoo K, McNicholas C, Saffer J, Bell D. Making change last: applying the NHS institute for innovation and improvement sustainability model to healthcare improvement. Implement Sci. 2013 Oct 26;8:127. doi: 10.1186/1748-5908-8-127. PMID: 24160758; PMCID: PMC3827618. Abstract

Gareth Parry, Astou Coly, Don Goldmann, Alexander K Rowe, Vijay Chattu, Deneil Logiudice, Mihajlo Rabrenovic, Bejoy Nambiar, Practical recommendations for the evaluation of improvement initiatives, International Journal for Quality in Health Care, Volume 30, Issue suppl_1, April 2018, Pages 29–36,doi.org/10.1093/intqhc/mzy021. Abstract

Clarke G M, Conti S, Wolters A T, Steventon A. Evaluating the impact of healthcare interventions using routine data BMJ 2019; 365 :l2239 doi:10.1136/bmj.l2239. Abstract

Seoane L, Winterbottom F, Nash T, Behrhorst J, Chacko E, Shum L, Pavlov A, Briski D, Thibeau S, Bergeron D, Rafael T, Sundell E. Using quality improvement principles to improve the care of patients with severe sepsis and septic shock. Ochsner J. 2013 Fall;13(3):359-66. PMID: 24052765; PMCID: PMC3776511. Abstract

Perlin JB, Jackson E, Hall C, Mindick A, Berberich G, Korwek K, Poland RE, Roach J, Novak A, Guy JS. 2019 John M. Eisenberg Patient Safety and Quality Awards: SPOTting Sepsis to Save Lives: A Nationwide Computer Algorithm for Early Detection of Sepsis: Innovation in Patient Safety and Quality at the National Level (Eisenberg Award). Jt Comm J Qual Patient Saf. 2020 Jul;46(7):381-391. doi: 10.1016/j.jcjq.2020.04.006. Epub 2020 Apr 19. PMID: 32598281. Abstract

Alnababteh MH, Huang SS, Ryan A, McGowan KM, Yohannes S. A Multimodal Sepsis Quality-Improvement Initiative Including 24/7 Screening and a Dedicated Sepsis Response Team-Reduced Readmissions and Mortality. Crit Care Explor. 2020 Nov 24;2(12):e0251. doi: 10.1097/CCE.0000000000000251. PMID: 33251514; PMCID: PMC7688252. Abstract

Wunderink RG, Srinivasan A, Barie PS, Chastre J, Dela Cruz CS, Douglas IS, Ecklund M, Evans SE, Evans SR, Gerlach AT, Hicks LA, Howell M, Hutchinson ML, Hyzy RC, Kane-Gill SL, Lease ED, Metersky ML, Munro N, Niederman MS, Restrepo MI, Sessler CN, Simpson SQ, Swoboda SM, Guillamet CV, Waterer GW, Weiss CH. Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM. Ann Am Thorac Soc. 2020 May;17(5):531-540. doi: 10.1513/AnnalsATS.202003-188ST. PMID: 32356696; PMCID: PMC7193806. Abstract

Teshome BF, Vouri SM, Hampton N, Kollef MH, Micek ST. Duration of Exposure to Antipseudomonal β-Lactam Antibiotics in the Critically Ill and Development of New Resistance. Pharmacotherapy. 2019 Mar;39(3):261-270. doi: 10.1002/phar.2201. Epub 2019 Jan 7. PMID: 30506852; PMCID: PMC6507412. Abstract

Strich JR, Heil EL, Masur H. Considerations for Empiric Antimicrobial Therapy in Sepsis and Septic Shock in an Era of Antimicrobial Resistance. J Infect Dis. 2020 Jul 21;222(Suppl 2):S119-S131. doi: 10.1093/infdis/jiaa221. PMID: 32691833; PMCID: PMC7372215. Abstract

Rhee C, Kadri SS, Dekker JP, et al. Prevalence of Antibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use. JAMA Netw Open. 2020;3(4):e202899. doi:10.1001/jamanetworkopen.2020.2899. Abstract

Zohal Rashidzada, Kelly A Cairns, Trisha N Peel, Adam W Jenney, Joseph S Doyle, Michael J Dooley, Allen C Cheng, Early antimicrobial stewardship team intervention on appropriateness of antimicrobial therapy in suspected sepsis: a randomized controlled trial, JAC-Antimicrobial Resistance, Volume 3, Issue 3, September 2021, dlab097, doi.org/10.1093/jacamr/dlab097. Abstract

Martínez ML, Plata-Menchaca EP, Ruiz-Rodríguez JC, Ferrer R. An approach to antibiotic treatment in patients with sepsis. J Thorac Dis. 2020 Mar;12(3):1007-1021. doi: 10.21037/jtd.2020.01.47. PMID: 32274170; PMCID: PMC7139065. Abstract

Theresa Madaline, Francis Wadskier Montagne, Ruth Eisenberg, Wenzhu Mowrey, Jaskiran Kaur, Maria Malik, Inessa Gendlina, Yi Guo, Deborah White, Liise-Anne Pirofski, Uzma Sarwar, Early Infectious Disease Consultation Is Associated With Lower Mortality in Patients With Severe Sepsis or Septic Shock Who Complete the 3-Hour Sepsis Treatment Bundle, Open Forum Infectious Diseases, Volume 6, Issue 10, October 2019, ofz408, doi.org/10.1093/ofid/ofz408. Abstract

De Waele JJ, Dhaese S. Antibiotic stewardship in sepsis management: toward a balanced use of antibiotics for the severely ill patient. Expert Rev Anti Infect Ther. 2019 Feb;17(2):89-97. doi: 10.1080/14787210.2019.1568239. Epub 2019 Jan 23. PMID: 30672354. Abstract

Burston J, Adhikari S, Hayen A, et al. A Role for Antimicrobial Stewardship in Clinical Sepsis Pathways: a Prospective Interventional Study. Infection Control & Hospital Epidemiology. 2017;38(9):1032-1038. doi:10.1017/ice.2017.139. Abstract

Pronovost P, Weast B, Schwarz M, Wyskiel RM, Prow D, Milanovich SN, Berenholtz S, Dorman T, Lipsett P. Medication reconciliation: a practical tool to reduce the risk of medication errors. J Crit Care. 2003 Dec;18(4):201-5. doi: 10.1016/j.jcrc.2003.10.001. PMID: 14691892. Abstract

Coleman EA, Smith JD, Raha D, Min S. Posthospital Medication Discrepancies: Prevalence and Contributing Factors. Arch Intern Med. 2005;165(16):1842–1847. doi:10.1001/archinte.165.16.1842. Abstract

Bell CM, Rahimi-Darabad P, Orner AI. Discontinuity of chronic medications in patients discharged from the intensive care unit. J Gen Intern Med. 2006 Sep;21(9):937-41. doi: 10.1111/j.1525-1497.2006.00499.x. PMID: 16918738; PMCID: PMC1831608. Abstract

Shen E, Koyama SY, Huynh DN, et al. Association of a Dedicated Post–Hospital Discharge Follow-up Visit and 30-Day Readmission Risk in a Medicare Advantage Population. JAMA Intern Med. 2017;177(1):132–135. doi:10.1001/jamainternmed.2016.7061. Abstract

Misky, GJ, Wald H, Coleman E.Post-hospitalization transitions: Examining the effects of timing of primary care provider follow-up. Journal of Hospital Medicine. 2010 June 23. doi/10.1002/jhm.666. Abstract

Coppa K, Kim EJ, Oppenheim MI, Bock KR, Conigliaro J, Hirsch JS. Examination of Post-discharge Follow-up Appointment Status and 30-Day Readmission. J Gen Intern Med. 2021 May;36(5):1214-1221. doi: 10.1007/s11606-020-06569-5. Epub 2021 Jan 19. PMID: 33469750; PMCID: PMC8131454. Abstract

Harrison JD, Archuleta M, Avitia E, Banta J, Benn J, Burden M, Chopra V, Coker R, Eid S, Fang MC, Fletcher K, Hagan J, Jaranilla J, Mullick M, Nyenpan C, Silva L, Wurst M, Ziegler G, Leykum L. Developing a Patient- and Family-Centered Research Agenda for Hospital Medicine: The Improving Hospital Outcomes through Patient Engagement (i-HOPE) Study. J Hosp Med. 2020 Jun;15(6):331-337. doi: 10.12788/jhm.3386. PMID: 32490806; PMCID: PMC7289507. Abstract

Jack BW, Chetty VK, Anthony D, Greenwald JL, Sanchez GM, Johnson AE, Forsythe SR, O'Donnell JK, Paasche-Orlow MK, Manasseh C, Martin S, Culpepper L. A reengineered hospital discharge program to decrease rehospitalization: a randomized trial. Ann Intern Med. 2009 Feb 3;150(3):178-87. doi: 10.7326/0003-4819-150-3-200902030-00007. PMID: 19189907; PMCID: PMC2738592. Abstract

Dudas V, Bookwalter T, Kerr KM, Pantilat SZ. The impact of follow-up telephone calls to patients after hospitalization. The American Journal of Medicine. 2001 Dec 21. DOI: 10.1016/S00002-9343(01)00966-4. Abstract

Trivedi SP, Corderman S, Berlinberg E, Schoenthaler A, Horwitz LI. Assessment of Patient Education Delivered at Time of Hospital Discharge. JAMA Intern Med. 2023;183(5):417–423. doi:10.1001/jamainternmed.2023.0070. Abstract

Kowalkowski MA, Rios A, McSweeney J, Murphy S, McWilliams A, Chou SH, Hetherington T, Rossman W, Taylor SP. Effect of a Transitional Care Intervention on Rehospitalization and Mortality after Sepsis: A 12-Month Follow-up of a Randomized Clinical Trial. Am J Respir Crit Care Med. 2022 Sep 15;206(6):783-786. doi: 10.1164/rccm.202203-0590LE. PMID: 35608544. Abstract

Chao PW, Shih CJ, Lee YJ, Tseng CM, Kuo SC, Shih YN, Chou KT, Tarng DC, Li SY, Ou SM, Chen YT. Association of postdischarge rehabilitation with mortality in intensive care unit survivors of sepsis. Am J Respir Crit Care Med. 2014 Nov 1;190(9):1003-11. doi: 10.1164/rccm.201406-1170OC. PMID: 25210792. Abstract

Becker C, Zumbrunn S, Beck K, et al. Interventions to Improve Communication at Hospital Discharge and Rates of Readmission: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021;4(8):e2119346. doi:10.1001/jamanetworkopen.2021.19346. Abstract

Pronovost P, Berenholtz S, Dorman T, Lipsett PA, Simmonds T, Haraden C. Improving communication in the ICU using daily goals. J Crit Care. 2003 Jun;18(2):71-5. doi: 10.1053/jcrc.2003.50008. PMID: 12800116. Abstract

Dunlay SM, Strand JJ. How to discuss goals of care with patients. Trends Cardiovasc Med. 2016 Jan;26(1):36-43. doi: 10.1016/j.tcm.2015.03.018. Epub 2015 Apr 3. PMID: 25933831; PMCID: PMC4592692. Abstract

Curtis JR, Lee RY, Brumback LC, et al. Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial. JAMA. 2023;329(23):2028–2037. doi:10.1001/jama.2023.8812. Abstract

Black, Martin D.1; Vigorito, Margaret C.2; Curtis, J. Randall3; Phillips, Gary S.4; Martin, Edward W.5; McNicoll, Lynn6; Rochon, Therese7; Ross, Susan1; Levy, Mitchell M.1. A Multifaceted Intervention to Improve Compliance With Process Measures for ICU Clinician Communication With ICU Patients and Families*. Critical Care Medicine 41(10):p 2275-2283, October 2013. | DOI: 10.1097/CCM.0b013e318298267. Abstract

Bernacki RE, Block SD, for the American College of Physicians High Value Care Task Force. Communication About Serious Illness Care Goals: A Review and Synthesis of Best Practices. JAMA Intern Med. 2014;174(12):1994–2003. doi:10.1001/jamainternmed.2014.5271. Abstract

Walsh TS, Salisbury LG, Merriweather JL, et al. Increased Hospital-Based Physical Rehabilitation and Information Provision After Intensive Care Unit Discharge: The RECOVER Randomized Clinical Trial. JAMA Intern Med. 2015;175(6):901–910. doi:10.1001/jamainternmed.2015.0822. Abstract

Uthup B, Myszenski A, Saigh N, Samuel PS. Evaluating the benefits of early rehabilitation intervention for patients with sepsis in the medical intensive care unit: A retrospective study. Journal of Acute Care Physical Therapy 2021. Abstract

Sossdorf M, Otto GP, Menge K, Claus RA, Lösche W, Kabisch B, Kohl M, Smolenski UC, Schlattmann P, Reinhart K, Winning J. Potential effect of physiotherapeutic treatment on mortality rate in patients with severe sepsis and septic shock: a retrospective cohort analysis. J Crit Care. 2013 Dec;28(6):954-8. doi: 10.1016/j.jcrc.2013.06.023. Epub 2013 Aug 17. PMID: 23958242. Abstract

Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009 May 30;373(9678):1874-82. doi: 10.1016/S0140-6736(09)60658-9. Epub 2009 May 14. PMID: 19446324; PMCID: PMC9906655. Abstract

Sakai Y, Yamamoto S, Karasawa T, Sato M, Nitta K, Okada M, Takeshige K, Ikegami S, Imamura H, Horiuchi H. Effects of early rehabilitation in sepsis patients by a specialized physical therapist in an emergency center on the return to activities of daily living independence: A retrospective cohort study. PLoS One. 2022 Mar 31;17(3):e0266348. doi: 10.1371/journal.pone.0266348. PMID: 35358285; PMCID: PMC8970360. Abstract

Rousseau, AF., Prescott, H.C., Brett, S.J. et al. Long-term outcomes after critical illness: recent insights. Crit Care 25, 108 (2021). https://doi.org/10.1186/s13054-021-03535-3. Abstract

Odden, A.J., Rohde, J.M., Bonham, C. et al. Functional outcomes of general medical patients with severe sepsis. BMC Infect Dis 13, 588 (2013). https://doi.org/10.1186/1471-2334-13-588. Abstract

Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis. JAMA. 2010;304(16):1787–1794. doi:10.1001/jama.2010.1553. Abstract

Starmer, AJ.et.al. Changes in Medical Errors after Implementation of a Handoff Program. 2014 Nov 6.N Engl J Med 2014;371:1803-1812.DOI: 10.1056/NEJMsa1405556. Vol 371. No 19. Abstract

Pun BT, Balas MC, Barnes-Daly MA, Thompson JL, Aldrich JM, Barr J, Byrum D, Carson SS, Devlin JW, Engel HJ, Esbrook CL, Hargett KD, Harmon L, Hielsberg C, Jackson JC, Kelly TL, Kumar V, Millner L, Morse A, Perme CS, Posa PJ, Puntillo KA, Schweickert WD, Stollings JL, Tan A, D'Agostino McGowan L, Ely EW. Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults. Crit Care Med. 2019 Jan;47(1):3-14. doi: 10.1097/CCM.0000000000003482. PMID: 30339549; PMCID: PMC6298815. Abstract

Santhosh L, Lyons PG, Rojas JC, Ciesielski TM, Beach S, Farnan JM, Arora V. Characterising ICU-ward handoffs at three academic medical centres: process and perceptions. BMJ Qual Saf. 2019 Aug;28(8):627-634. doi: 10.1136/bmjqs-2018-008328. Epub 2019 Jan 12. PMID: 30636201. Abstract

Parsons Leigh J, Brundin-Mather R, Whalen-Browne L, Kashyap D, Sauro K, Soo A, Petersen J, Taljaard M, Stelfox HT. Effectiveness of an Electronic Communication Tool on Transitions in Care From the Intensive Care Unit: Protocol for a Cluster-Specific Pre-Post Trial. JMIR Res Protoc. 2021 Jan 8;10(1):e18675. doi: 10.2196/18675. PMID: 33416509; PMCID: PMC7822720. Abstract

ICU Transfer Summary Consensus Panel,; de Grood C, Job McIntosh C, Boyd JM, Zjadewicz K, Parsons Leigh J, Stelfox HT. Identifying essential elements to include in Intensive Care Unit to hospital ward transfer summaries: A consensus methodology. J Crit Care. 2019 Feb;49:27-32. doi: 10.1016/j.jcrc.2018.10.001. Epub 2018 Oct 6. PMID: 30343010. Abstract

Serpa Neto A, Cardoso SO, Manetta JA, et al. Association Between Use of Lung-Protective Ventilation With Lower Tidal Volumes and Clinical Outcomes Among Patients Without Acute Respiratory Distress Syndrome: A Meta-analysis. JAMA. 2012;308(16):1651–1659. doi:10.1001/jama.2012.13730. Abstract

Angus DC, Seymour CW, Bibbins-Domingo K. Caring for Patients With Acute Respiratory Distress Syndrome: Summary of the 2023 ESICM Practice Guidelines. JAMA. 2023;330(4):368–371. doi:10.1001/jama.2023.6812. Abstract

Strich JR, Heil EL, Masur H. Considerations for Empiric Antimicrobial Therapy in Sepsis and Septic Shock in an Era of Antimicrobial Resistance. J Infect Dis. 2020 Jul 21;222(Suppl 2):S119-S131. doi: 10.1093/infdis/jiaa221. PMID: 32691833; PMCID: PMC7372215. Abstract

Amoah J, Klein EY, Chiotos K, Cosgrove SE, Tamma PD. Administration of a β-Lactam Prior to Vancomycin as the First Dose of Antibiotic Therapy Improves Survival in Patients With Bloodstream Infections. Clin Infect Dis. 2022 Aug 24;75(1):98-104. doi: 10.1093/cid/ciab865. PMID: 34606585. Abstract

Zampieri FG, Machado FR, Biondi RS, Freitas FGR, Veiga VC, Figueiredo RC, Lovato WJ, Amêndola CP, Serpa-Neto A, Paranhos JLR, Lúcio EA, Oliveira-Júnior LC, Lisboa TC, Lacerda FH, Maia IS, Grion CMC, Assunção MSC, Manoel ALO, Corrêa TD, Guedes MAVA, Azevedo LCP, Miranda TA, Damiani LP, Brandão da Silva N, Cavalcanti AB. Association between Type of Fluid Received Prior to Enrollment, Type of Admission, and Effect of Balanced Crystalloid in Critically Ill Adults: A Secondary Exploratory Analysis of the BaSICS Clinical Trial. Am J Respir Crit Care Med. 2022 Jun 15;205(12):1419-1428. doi: 10.1164/rccm.202111-2484OC. PMID: 35349397. Abstract

Rochwerg B, Alhazzani W, Sindi A, Heels-Ansdell D, Thabane L, Fox-Robichaud A, Mbuagbaw L, Szczeklik W, Alshamsi F, Altayyar S, Ip WC, Li G, Wang M, Wludarczyk A, Zhou Q, Guyatt GH, Cook DJ, Jaeschke R, Annane D; Fluids in Sepsis and Septic Shock Group. Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med. 2014 Sep 2;161(5):347-55. doi: 10.7326/M14-0178. PMID: 25047428. Abstract

Jackson KE, Wang L, Casey JD, Bernard GR, Self WH, Rice TW, Semler MW; SMART Investigators and the Pragmatic Critical Care Research Group. Effect of Early Balanced Crystalloids Before ICU Admission on Sepsis Outcomes. Chest. 2021 Feb;159(2):585-595. doi: 10.1016/j.chest.2020.08.2068. Epub 2020 Aug 31. PMID: 32882244; PMCID: PMC7856532. Abstract

Hammond, N.E. et al.Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis. 2022 Jan 18. NEJM Evid 2022;1(2).DOI: 10.1056/EVIDoa2100010. Vol 1. No.2. Abstract

Brown RM, Wang L, Coston TD, Krishnan NI, Casey JD, Wanderer JP, Ehrenfeld JM, Byrne DW, Stollings JL, Siew ED, Bernard GR, Self WH, Rice TW, Semler MW. Balanced Crystalloids versus Saline in Sepsis. A Secondary Analysis of the SMART Clinical Trial. Am J Respir Crit Care Med. 2019 Dec 15;200(12):1487-1495. doi: 10.1164/rccm.201903-0557OC. PMID: 31454263; PMCID: PMC6909845. Abstract

Bledsoe J, Peltan ID, Bunnell RJ, et al. Order Substitutions and Education for Balanced Crystalloid Solution Use in an Integrated Health Care System and Association With Major Adverse Kidney Events. JAMA Netw Open. 2022;5(5):e2210046. doi:10.1001/jamanetworkopen.2022.10046. Abstract

Rygård SL, Butler E, Granholm A, Møller MH, Cohen J, Finfer S, Perner A, Myburgh J, Venkatesh B, Delaney A. Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis. Intensive Care Med. 2018 Jul;44(7):1003-1016. doi: 10.1007/s00134-018-5197-6. Epub 2018 May 14. PMID: 29761216. Abstract

Fang F, Zhang Y, Tang J, et al. Association of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis. JAMA Intern Med. 2019;179(2):213–223. doi:10.1001/jamainternmed.2018.5849. Abstract

Bosch NA, Teja B, Law AC, Pang B, Jafarzadeh SR, Walkey AJ. Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock. JAMA Intern Med. 2023;183(5):451–459. doi:10.1001/jamainternmed.2023.0258. Abstract

 Permpikul C, Tongyoo S, Viarasilpa T, Trainarongsakul T, Chakorn T, Udompanturak S. Early Use of Norepinephrine in Septic Shock Resuscitation (CENSER). A Randomized Trial. Am J Respir Crit Care Med. 2019 May 1;199(9):1097-1105. doi: 10.1164/rccm.201806-1034OC. PMID: 30704260. Abstract

De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL; SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010 Mar 4;362(9):779-89. doi: 10.1056/NEJMoa0907118. PMID: 20200382. Abstract

Cardenas-Garcia J, Schaub KF, Belchikov YG, Narasimhan M, Koenig SJ, Mayo PH. Safety of peripheral intravenous administration of vasoactive medication. J Hosp Med. 2015 Sep;10(9):581-5. doi: 10.1002/jhm.2394. Epub 2015 May 26. PMID: 26014852. Abstract

Avni T, Lador A, Lev S, Leibovici L, Paul M, Grossman A. Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis. PLoS One. 2015 Aug 3;10(8):e0129305. doi: 10.1371/journal.pone.0129305. PMID: 26237037; PMCID: PMC4523170. Abstract

Zampieri FG, Bagshaw SM, Semler MW. Fluid Therapy for Critically Ill Adults With Sepsis: A Review. JAMA. 2023;329(22):1967–1980. doi:10.1001/jama.2023.7560. Abstract

Meyhoff, T.S. et al. Restriction of Intravenous Fluid in ICU Patients with Septic Shock. 2022 July 17. N Engl J Med 2022;386:2459-2470. DOI: 10.1056/NEJMoa2202707. VOL 386. No. 26. Abstract

Kuttab HI, Lykins JD, Hughes MD, Wroblewski K, Keast EP, Kukoyi O, Kopec JA, Hall S, Ward MA. Evaluation and Predictors of Fluid Resuscitation in Patients With Severe Sepsis and Septic Shock. Crit Care Med. 2019 Nov;47(11):1582-1590. doi: 10.1097/CCM.0000000000003960. PMID: 31393324; PMCID: PMC8096207. Abstract

Acharya R, Patel A, Schultz E, Bourgeois M, Kandinata N, Paswan R, Kafle S, Sedhai YR, Younus U. Fluid resuscitation and outcomes in heart failure patients with severe sepsis or septic shock: A retrospective case-control study. PLoS One. 2021 Aug 19;16(8):e0256368. doi: 10.1371/journal.pone.0256368. PMID: 34411178; PMCID: PMC8376054. Abstract.

Seymour CW, Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, Lemeshow S, Osborn T, Terry KM, Levy MM. Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. N Engl J Med. 2017 Jun 8;376(23):2235-2244. doi: 10.1056/NEJMoa1703058. Epub 2017 May 21. PMID: 28528569; PMCID: PMC5538258. Abstract

Peltan ID, Brown SM, Bledsoe JR, Sorensen J, Samore MH, Allen TL, Hough CL. ED Door-to-Antibiotic Time and Long-term Mortality in Sepsis. Chest. 2019 May;155(5):938-946. doi: 10.1016/j.chest.2019.02.008. Epub 2019 Feb 16. PMID: 30779916; PMCID: PMC6533450. Abstract

Liu VX, Fielding-Singh V, Greene JD, Baker JM, Iwashyna TJ, Bhattacharya J, Escobar GJ. The Timing of Early Antibiotics and Hospital Mortality in Sepsis. Am J Respir Crit Care Med. 2017 Oct 1;196(7):856-863. doi: 10.1164/rccm.201609-1848OC. PMID: 28345952; PMCID: PMC5649973. Abstract

Liu VX, Morehouse JW, Marelich GP, Soule J, Russell T, Skeath M, Adams C, Escobar GJ, Whippy A. Multicenter Implementation of a Treatment Bundle for Patients with Sepsis and Intermediate Lactate Values. Am J Respir Crit Care Med. 2016 Jun 1;193(11):1264-70. doi: 10.1164/rccm.201507-1489OC. PMID: 26695114; PMCID: PMC4910898. Abstract

Ballester L, Martínez R, Méndez J, Miró G, Solsona M, Palomera E, Capdevila JA, Rodriguez A, Yébenes JC. Differences in Hypotensive vs. Non-Hypotensive Sepsis Management in the Emergency Department: Door-to-Antibiotic Time Impact on Sepsis Survival. Med Sci (Basel). 2018 Oct 10;6(4):91. doi: 10.3390/medsci6040091. PMID: 30309044; PMCID: PMC6313793. Abstract

Uffen JW, Oosterheert JJ, Schweitzer VA, Thursky K, Kaasjager HAH, Ekkelenkamp MB. Interventions for rapid recognition and treatment of sepsis in the emergency department: a narrative review. Clin Microbiol Infect. 2021 Feb;27(2):192-203. doi: 10.1016/j.cmi.2020.02.022. Epub 2020 Feb 29. PMID: 32120030. Abstract

Schorr C, Odden A, Evans L, Escobar GJ, Gandhi S, Townsend S, Levy M. Implementation of a multicenter performance improvement program for early detection and treatment of severe sepsis in general medical-surgical wards. J Hosp Med. 2016 Nov;11 Suppl 1:S32-S39. doi: 10.1002/jhm.2656. PMID: 27805796. Abstract

Scheer CS, Fuchs C, Gründling M, Vollmer M, Bast J, Bohnert JA, Zimmermann K, Hahnenkamp K, Rehberg S, Kuhn SO. Impact of antibiotic administration on blood culture positivity at the beginning of sepsis: a prospective clinical cohort study. Clin Microbiol Infect. 2019 Mar;25(3):326-331. doi: 10.1016/j.cmi.2018.05.016. Epub 2018 Jun 4. PMID: 29879482. Abstract

Delawder JM, Hulton L. An Interdisciplinary Code Sepsis Team to Improve Sepsis-Bundle Compliance: A Quality Improvement Project. J Emerg Nurs. 2020 Jan;46(1):91-98. doi: 10.1016/j.jen.2019.07.001. Epub 2019 Sep 25. PMID: 31563282. Abstract

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