HMS Articles of Interest

HMS Articles


Prescott HC, Heath M, Munroe ES, Blamoun J, Bozyk P, Hechtman RK, Horowitz JK, Jayaprakash N, Kocher KE, Younas M, Parks Taylor S, Posa P, Mclaughlin E, Flanders SA. Development and validation of the HMS-Sepsis mortality model. Chest. 2 July 2024. S0012-3692(24)04571-9. doi: 10.1016/j.chest.2024.06.3769. Abstract

Heath M, Bernstein SJ, Paje D, McLaughlin E, Horowitz JK, McKenzie A, Leyden T, Flanders SA, Chopra V. Improving Appropriate Use of Peripherally Inserted Central Catheters Through a Statewide Collaborative Hospital Initiative, a Cost-Effectiveness Analysis. The Joint Commission Journal on Quality and Patient Safety. Published online 10 April 2024. doi:10.1016/j.jcjq.2024.04.003. Abstract

Gupta AB, Flanders SA, Petty LA, et al. Inappropriate Diagnosis of Pneumonia Among Hospitalized Adults. JAMA Intern Med. Published online 25 March 2024. doi:10.1001/jamainternmed.2024.0077. Abstract

Advani SD, Ratz D, Horowitz JK, et al. Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria. JAMA Netw Open. 2024;7(3):e242283. doi:10.1001/jamanetworkopen.2024.2283. Abstract

Szymczak JE, Petty LA, Gandhi TN. et al. Protocol for a parallel cluster randomized trial of a participatory tailored approach to reduce overuse of antibiotics at hospital discharge: the ROAD home trial. Implementation Sci. 2024 March 4. Abstract

White A, Vaughn V, Petty L, Gandhi T, Horowitz J, et al. Development of patient safety measures to identify inappropriate diagnosis of common infections. Clinical Infectious Diseases. 2024 January 31.doi.10.1093/cid/ciae044. Abstract


Quinn M, Horowitz J, Krein S, Gaston A, Ullman A, Chopra V. The role of hospital-based vascular access teams and implications for patient safety: A multi-methods study. J Hosp Med. 2023 December 15. doi:10.1002/jhm.13253. Abstract

Vaughn V, Krein S, Hersh A, et al. Excellence in Antibiotic Stewardship: A mixed methods study comparing High, Medium, and Low Performing Hospitals. Clinical Infectious Diseases. December 2023. doi:10.1093/cid/ciad743. Abstract

Lóser MK, Horowitz JH, England P, Esteitie R, Kaatz S, McLaughlin E, Munroe E, Heath M, Posa P, Flanders S, Prescott HC. Institutional Structures and Processes to Support Sepsis Care: A Multihospital Study. Critical Care Explorations. November 2023. doi: 10.1097/CCE.0000000000001004. Abstract

Munroe ES, Heath ME, Eteer M, Gershengorn HB, Horowitz JK, Jones J, Kaatz S, Tamae Kakazu M, McLaughlin E, Flanders SA, Prescott HC. Use and outcomes of peripheral vasopressors in early sepsis-induced hypotension across Michigan hospitals: a retrospective cohort study. Chest. 2023 Oct 26:S0012-3692(23)05672-6. doi: 10.1016/j.chest.2023.10.027. Epub ahead of print. PMID: 37898185. Abstract

  • Barbash IJ. Real World Data on Peripheral Vasopressors in Septic Shock. CHEST. 2024 April. doi:10.1016/j.chest.2023.11.005. Editorial 

Paje D, Heath M, Heung M, et al. Midline catheters in patients with advanced chronic kidney disease. J Hosp Med. 2023 September 29; 1-9. doi:10.1002/jhm.13209. Abstract

Prescott HC, Posa PJ, Dantes R. The Centers for Disease Control and Prevention’s Hospital Sepsis Program Core Elements. JAMA. Published online August 24, 2023. doi:10.1001/jama.2023.16693. Abstract

Dantes R, Kaur H, Bouwkamp B, Haass K, Patel P, et. al. Sepsis Program Activities in Acute Care Hospitals — National Healthcare Safety Network, United States, 2022. MMWR. 2023 August 25. Abstract 

Vaughn VM, Gupta A, Petty LA, et al. A Statewide Quality Initiative to Reduce Unnecessary Antibiotic Treatment of Asymptomatic Bacteriuria. JAMA Intern Med. Published online July 10, 2023. doi:10.1001/jamainternmed.2023.2749. Abstract

Gershengorn HB, Basu T, Horowitz JK, McLaughlin E, Munroe E, O'Malley M, Hsaiky L, Flanders SA, Bernstein SJ, Paje D, Chopra V, & Prescott HC. (2023). The Association of Vasopressor Administration Through a Midline Catheter with Catheter-Related Complications. Annals of the American Thoracic Society, 10.1513/AnnalsATS.202209-814OC. Advance online publication. Abstract


Ray-Barruel G, Horowitz J, McLaughlin E, Flanders S, Chopra V. Barriers and facilitators for implementing peripherally inserted central catheter (PICC) appropriateness guidelines: A longitudinal survey study from 34 Michigan hospitals. PLoS ONE. 2022 Nov 4. 17(11): e0277302. Abstract

Mitbander UB, Geer MJ, Taxbro K, Horowitz JK, Zhang Q, O'Malley ME, Ramnath N, and Chopra, V. Patterns of use and outcomes of peripherally inserted central catheters in hospitalized patients with solid tumors: A multicenter study. Cancer. Published online 9 August 2022. Abstract

Govindan S, O'Malley ME, Flanders SA, Chopra V. The MI-PICC Score: A Risk-Prediction Model for PICC-Associated Complications in the ICU. Am J Respir Crit Care Med. 2022 Jul 21. doi: 10.1164/rccm.202204-0760LE. Epub ahead of print. PMID: 35862722. Abstract

Munroe E, Claar D, Tamae-Kakazu M, Tatem G, Blamoun J, McSparron JI, Prescott HC. Hospital Policies on Intravenous Vasopressor Administration and Monitoring: A Survey of Michigan Hospitals. Ann Am Thorac Soc. 2022 May 24. doi: 10.1513/AnnalsATS.202203-197RL. Epub ahead of print. PMID: 35608405. Abstract

Vaughn VM, Ratz D, Greene T, Flanders SA, et al. Antibiotic Stewardship Strategies and Their Association with Antibiotic Overuse after Hospital Discharge: An Analysis of the Reducing Overuse of Antibiotics at Discharge (Road) Home Framework. Clinical Infectious Diseases. 2022 Feb 10. Abstract

Gupta A, Petty L, Gandhi T, Flanders S, Hsaiky L, Basu T, Zhang Q, Horowitz J, Masood Z, Chopra V, Vaughn VM. Overdiagnosis of urinary tract infection linked to overdiagnosis of pneumonia: a multihospital cohort study. BMJ Qual Saf. 2022 May;31(5):383-386. doi: 10.1136/bmjqs-2021-013565. Epub 2022 Jan 5. PMID: 34987084; PMCID: PMC9121367. Abstract


Swaminathan L, Flanders S, Horowitz J, Zhang Q, O'Malley M, Chopra V. Safety and Outcomes of Midline Catheters vs Peripherally Inserted Central Catheters for Patients With Short-term Indications: A Multicenter Study. JAMA Intern Med. 2021 Nov 29. doi: 10.1001/jamainternmed.2021.6844. Epub ahead of print. PMID: 34842905. Abstract
Vaughn VM, Gandhi TN, Hofer TP, Petty LA, Malani AN, Osterholzer D, Dumkow LE, Ratz D, Horowitz JK, McLaughlin ES, Czilok T, Flanders SA. A Statewide Collaborative Quality Initiative To Improve Antibiotic Duration And Outcomes Of Patients Hospitalized With Uncomplicated Community-Acquired Pneumonia. Clin Infect Dis. 2021 Nov 13. doi: 10.1093/cid/ciab950. Epub ahead of print. Abstract
Vaughn VM, Hersh AL, Spivak ES. Antibiotic Overuse and Stewardship at Hospital Discharge: The Reducing Overuse of Antibiotics at Discharge (ROAD) Home Framework. Clinical Infectious Diseases. Published online 23 September 2021. Abstract
Ullman AJ, Paterson RS, Schults JA, Kleidon TM, August D, O'Malley M, Horowitz J, Rickard CM, Paje D, Chopra V. Do antimicrobial and antithrombogenic peripherally inserted central catheter (PICC) materials prevent catheter complications? An analysis of 42,562 hospitalized medical patients. Infect Control Hosp Epidemiol. 2021 Apr 28:1-8. doi: 10.1017/ice.2021.141. Epub ahead of print. PMID: 33908337. Abstract
Chopra V, O'Malley M, Horowitz J, et al. Improving peripherally inserted central catheter appropriateness and reducing device-related complications: a quasiexperimental study in 52 Michigan hospitals. BMJ Quality & Safety. Published Online First: 29 March 2021. doi: 10.1136/bmjqs-2021-013015. Abstract
Govindan S, Jobe A, O'Malley ME, Flanders SA, Chopra V. To PICC or not to PICC? A cross-sectional survey of vascular access practices in the ICU. J Crit Care. 2021 Feb 20;63:98-103. doi: 10.1016/j.jcrc.2021.02.004. Epub ahead of print. PMID: 33652363. Abstract


Petty LA, Vaughn V, Flanders SA, Patel T, Malani AN, Ratz D, Kaye KS, Pogue JM, Dumkow LE, Thyagarajan R, Hsaiky LM, Osterholzer D, Kronick SL, McLaughlin E, Gandhi TN. Assessment of Testing and Treatment of Asymptomatic Bacteriuria Initiated in the Emergency Department. Open Forum Infectious Diseases. Published online 03 November 2020. doi:10.1093/ofid/ofaa537. Abstract

Vaughn V, O'Malley M, Flanders SA, et al. Association of Infectious Disease Physician Approval of Peripherally Inserted Central Catheter With Appropriateness and Complications. JAMA Network Open. Published online 21 October 2020. doi:10.1001/jamanetworkopen.2020.17659. Abstract

Vaughn V, Gandhi TN, Chopra, C, et al. Antibiotic Overuse after Hospital Discharge: A Multi-Hospital Cohort Study. Clinical Infectious Diseases. Published online 11 September 2020. doi:10.1093/cid/ciaa1372. Abstract

Vaughn V, Gandhi TN, Petty LA, Patel PK, et al. Empiric Antibacterial Therapy and Community-onset Bacterial Co-infection in Patients Hospitalized with COVID-19: A Multi-Hospital Cohort Study. Clinical Infectious Diseases. Published online 21 August 2020. doi:10.1093/cid/ciaa1239 Abstract

Kleidon T, Horowitz J,  Rickard C, Ullman A, Marsh N, Schults J, Ratz D, Chopra V. Peripherally Inserted Central Catheter Thrombosis Following placement via electrocardiography vs. traditional methods: an analysis of 42,687 patients. The American Journal of Medicine. Published online 13 July 2020. doi:10.1016/j.amjmed.2020.06.010 Abstract 

Chen S, O'Malley M, Chopra V. How common are indwelling devices in hospitalized adults? A contemporary point prevalence study in a tertiary care hospital. American Journal of Infection Control. 49(2):194-197. Published online 30 March 2020. Abstract

Chopra V. Making MAGIC: how to improve the use of peripherally inserted central catheters. BMJ Quality & Safety. Published online 27 March 2020. doi: 10.1136/bmjqs-2019-010640 Abstract (Editorial)

Vaughn V, Petty L, Flanders S, Malani A, Patel T, Bernstein S, Hsaiky L, Thyagarajan R, Osterholzer D, McLaughlin E, Horowitz J, Gandhi T. A Deeper Dive Into Antibiotic Stewardship Needs: A Multihospital Survey, Open Forum Infectious Diseases, Volume 7, Issue 3. Published online 11 January 2020. Abstract


Petty L, et al. Risk Factors and Outcomes Associated With Treatment of Asymptomatic Bacteriuria in Hospitalized Patients. JAMA Int Med. Published Online 26 August 2019. Abstract

Vaughn V, et al. Excess Antibiotic Treatment Duration and Adverse Events in Patients Hospitalized With Pneumonia: A Multihospital Cohort Study. Ann Intern Med. Published Online 8 July 2019. Abstract

Paje D, et al. Use of Peripherally Inserted Central Catheters in Patients With Advanced Chronic Kidney Disease: A Prospective Cohort Study. Ann Intern Med. Published Online 2 July 2019. Abstract 

Chopra V, Kaatz S, Swaminathan L, Boldenow T, Snyder A, Burris R, Bernstein SJ, Flanders S. Variation in use and outcomes related to midline catheters: results from a multicentre pilot study. BMJ Quality & Safety. Published Online First: March 18, 2019. doi: 10.1136/bmjqs-2018-008554 Abstract

Vaughn V, Gandhi T, Conlon A, Chopra V, Malani A, Flanders SA. The Association of Antibiotic Stewardship with Fluoroquinolone Prescribing in Michigan Hospitals: A Multi-hospital Cohort Study. Clinical Infectious Diseases. Published online February 13, 2019. Abstract


Govindan S, Snyder A, Flanders SA, Chopra V. Peripherally Inserted Central Catheters in the ICU: A Retrospective Study of Adult Medical Patients in 52 Hospitals. Critical Care Medicine. Published online September 1, 2018. doi: 10.1097/CCM.0000000000003423. Abstract

Grant P, Conlon A, Chopra V, Flanders, S. Use of Venous Thromboembolism Prophylaxis in Hospitalized Patients. JAMA Internal Medicine. Published Online May 21, 2018. Abstract

Chopra V, Kaatz S, Grant P, Swaminathan L, Boldenow T, Conlon A, Bernstein S, Flanders S. Risk of Venous Thromboembolism Following Peripherally Inserted Central Catheter Exchange: an Analysis of 23,000 Hospitalized Patients. The American Journal of Medicine. Published online February 1, 2018. Abstract

Paje D, Conlon A, Kaatz S, Swaminathan L, Boldenow T, Bernstein S, Flanders SA, Chopra V, Patterns and Predictors of Short-Term Peripherally Inserted Central Catheter Use: A Multicenter Prospective Cohort Study. J. Hosp. Med. 2018 February;13(2):76-82. Abstract


Smith, Shawna N. et al. Patterns and Predictors of Peripherally Inserted Central Catheter Occlusion: The 3P-O Study. Journal of Vascular and Interventional Radiology. 2017;2(5). Abstract

Swaminathan L, Flanders S, Rogers M, et al. Improving PICC use and outcomes in hospitalised patients: an interrupted time series study using MAGIC criteria. BMJ Qual Saf Published Online First. 2017;0:1–8. Abstract

Chopra V, Kaatz S, Conlon A, Paje D, Grant P, Rogers M, Bernstein S, Saint S, Flanders F. The Michigan Risk Score to Predict Peripherally Inserted Central Catheter-associated Thrombosis. Journal of Thrombosis and Haemostasis. 2017 Oct;15(10):1951-1962. Abstract

Herc E, Patel P, Washer L, Conlon A, Flanders S, Chopra V. A Model to Predict Central-Line-Associated Bloodstream Infection Among Patients With Peripherally Inserted Central Catheters: The MPC Score. Infection Control & Hospital Epidemiology. 2017 Oct;38(10):1155-1166. Abstract


Greene T, Chopra V, Grant P, et al. Validation of Risk Assessment Models of Venous Thromboembolism in Hospitalized Medical Patients. Am J Med. 2016;129(9):1001.e9-1001. Abstract

Chopra V, Ratz D, Hofer T, et al. Limiting the Number of Lumens in Peripherally Inserted Central Catheters to Improve Outcomes and Reduce Cost: A Simulation Study. Infect Control Hosp Epidemiol. 2016;37(7):811-7. Abstract

Chopra V, Smith S, Swaminathan L, et al. Variations in Peripherally Inserted Central Catheters Use and Outcomes in Michigan Hospitals. JAMA Internal Medicine. 2016;176(4):548-551. Abstract

Moureau N, Chopra V. Making the Magic: Guiding Vascular Access Selection for Intensive Care - a Summary of Michigan Appropriateness Guide for Intravenous Catheters (MAGIC). ICU Management & Practice. 2016;16(2). AbstractDashboard

Moureau N, Chopra V. Indications for Peripheral, Midline and Central Catheters: Summary of the MAGIC Recommendations. Br J Nurse. 2016;25(8):S15-24. Abstract

Rogers M, Blumberg N, Bernstein S, Flanders S, Chopra V. Association Between Delivery Methods for Red Blood Cell Transfusion and the Risk of Venous Thromboembolism: a Longitudinal Study. The Lancet. 2016;3(12):563-571. Abstract


Chopra V, Kuhn L, Ratz D, et al.  Vascular Nursing Experience, Practice Knowledge, and Beliefs: Results from the Michigan PICC1 Survey. J Hosp Med. Published online December 30, 2015. doi: 10.1002/jhm.2523.  Abstract

Angelini D, Greene T, Wietzke J, Flanders S, Sood S. Defining the Risk: Benefit Ratio of Venous Thromboembolism (VTE) Prophylaxis in Hospitalized Cancer Patients. Blood. December, 2015;126(23):627. Abstract

Chopra V, Flanders S. Revisiting the tale of venous thromboembolism in hospitalized medical patients. J Thromb Haemost. 2015;13(12):2152-4. Abstract

Grant P, Greene T, Chopra V, et al.  Assessing the Caprini Score for Risk Assessment of Venous Thromboembolism in Hospitalized Medical Patients.  Am J Med. Published online November 6, 2015.  doi: 10.1016/j.amjmed.2015.10.027. Abstract

Chopra V, Flanders S, Saint S, et al. The Michigan Appropriateness Guide for Intravenous Catheters (MAGIC): Results From a Multispecialty Panel Using the RAND/UCLA Appropriateness Method. Ann Intern Med. 2015;163(6_Supplement):S1-S40. Abstract

Grant P, Flanders S. Venous Thromboembolism Prophylaxis: a Path Toward More Appropriate Use. BMJ Quality and Safety. 2015;24:605-607. Abstract

Greene T, Flanders S, Woller S, et al.  The Association Between PICC Use and Venous Thromboembolism in Upper and Lower Extremities. Am J Med. Published online May 1, 2015. doi: 10.1016/j.amjmed.2015.03.028. Abstract


Flanders S, Greene T, Grant P, et al. Hospital Performance for Pharmacologic Venous Thromboembolism Prophylaxis and Rate of Venous Thromboembolism : A Cohort Study. JAMA Intern Med. Published online August 18, 2014. doi:10.1001/jamainternmed.2014.3384. Abstract

Chopra V, Govindan S, Kuhn L, et al. Do Clinicians Know Which of Their Patients Have Central Venous Catheters?: A Multicenter Observational Study. Ann Intern Med. 2014;161: 562-7. Abstract

Chopra V, Ratz D, Kuhn L, et al. Peripherally Inserted Central Catheter-Related Deep Vein Thrombosis: Contemporary Patterns and Predictors.  J Thromb Haemost. 2014;12(6):847-54.  Abstract


Chopra V, Anand S, Hickner A, et al.  Risk of Venous Thromboembolism Associated with Peripherally Inserted Central Catheters: A Systematic Review and Meta-Analysis.  Lancet. 2013;382(9889):311-25.  Abstract

Chopra V, Kuhn L, Coffey CE Jr, et al. Hospitalist Experiences, Practice, Opinions, and Knowledge Regarding Peripherally Inserted Central Catheters: A Michigan Survey. J Hosp Med. 2013;8(6):309-14.  Abstract